SNP racial variations in ovari

International Union for the Ovarian Cancer Institute by analyzing more than more than 20,000 study found and validated 6 common ovarian cancer susceptibility of single nucleotide polymorphism (SNP, which are located in BNC2, HOXD1, 8q24, TiPARP, SKAP1 level and regional). In addition, the United States surveillance, epidemiology and end results (SEER) database information indicates that ovarian cancer incidence rates lower than whites in black 31%.　　In addition to producing inferior epidemiological risk factors may make some explanations, United States, Duke University Medical Center boqieke (Berchuck) study further tips, BNC2, HOXD1 and MERIT40 areas of SNP racial variation may also play an important role.　　The studies in the United States, Utah human polymorphism study center in Southwest China has selected black African nationality (ASW group, 57, 114 chromosomes) and Nordic white or Western European nationality (CEU group 113, 226 chromosomes). Results showed that two SNP (8q24, and TiPARP) in high risk allele frequency in black and white room is basically the same. Except 1 species SNP (SKAP1) due to ASW group data insufficient cannot assessment outside, remaining 3 species SNP (BNC2, and HOXD1 and MERIT40) of high risk, bit gene frequency in CEU group of occurred rate significantly higher than ASW group: near BNC2 of rs3814113 bit points, in ASW group of high risk, bit gene frequency is 42%, in CEU group for 63%;HOXD1 of rs2072590 bit points, in ASW group of high risk, bit gene frequency is 9%,　　In the CEU group 36%; near rs8170 point MERIT40, ASW group is 11%,CEU set to 21%. In addition, applying the 3 high risk allele frequency of racial variation predictable United States ovarian cancer incidence than whites of blacks in low 17.6% . www.cmt.com.cn